TiLLIRI study

A prospective observational multi-centre study to assess the risk factors that contribute to thrombosis in patients with lower limb injuries requiring immobilisation to identify a group of patients with a high predicted venous thrombo-embolism risk (VTE) risk. (TiLLIRI)


The TiLLIRI study has been approved by the Research Ethics Committee to commence recruitment in the Mater University Hospital Emergency Department & Smithfield Rapid Injury Clinic.

We are one of 7 centres conducting this national study aimed at identifying high-risk patient that may benefit from anti-coagulation to prevent a DVT after sustaining a lower limb injury that requires immobilisation.

Our aim is to recruit 500 clients in the next 3 years. We would like to invite you to participate in our study by enrolling patients that fulfil the inclusion criteria (see below).


You can find all the required documents in the TiLLIRI study recruiter pack v6.

Please do not hesitate to contact Dr Mohamed Qotb if you have any queries about the recruitment process.


We can’t thank you enough for your help. Together we can improve patient care!


Inclusion Criteria:

  • age ≥ 18 years
  • lower limb injuries (all patient included: out-patient management & admitted patients)
  • requiring immobilisation (cast, splint or boot)

Exclusion Criteria:

  • age < 18 years
  • unable to give consent (unconscious & no guardian present, lacks capacity or does not understand the English information leaflet and is unable to give informed consent)


Please find attached a list of Frequently Asked Questions: TiLLIRI FAQ v3